Background:Paxil is a prescription-only antidepressant (CPA) and commonly used to manage severe depressive episodes in adults. However, it is not as effective as the usual antidepressant. In addition, it has been found to be associated with increased sedative effects and increased risk of drowsiness and other adverse effects, as well as with a greater risk of falls. This study investigated whether paroxetine is associated with sedation and/or falls in patients taking selective serotonin reuptake inhibitors (SSRIs) and whether the combination with paroxetine is associated with an increased risk of drowsiness and falls.
Methods:We performed a retrospective cohort study using a database from the Danish National Patient Register. Inclusion criteria included patients taking paroxetine, including patients who had been on or within the last 2 weeks before paroxetine therapy and who were at least 40 mg/day. Exclusion criteria included patients with contraindications to paroxetine, including those who were older than 18 years, patients with known hepatic or renal disease or with a history of drug-induced sedation, patients who had a history of bleeding disorders or hypersensitivity to paroxetine, and patients with known history of severe cardiovascular disease or cardiac arrhythmias, or concomitant use of monoamine oxidase inhibitors (MAOIs) or thiazides. The following criteria were used for the inclusion: patients who were treated with paroxetine, including patients who were aged 20 to 80 years, patients with a history of cardiovascular or cerebrovascular disease, and patients who had a history of sedation and/or falls. Data were collected using a structured patient information form. All relevant data were obtained from the patient record and the data obtained from the medical record. All statistical analyses were performed using IBM SPSS Statistics for Windows (IBM Corp., Armonk, NY). P<0.05 was considered statistically significant. Results: There was no significant difference between paroxetine and paroxetine plus paroxetine in the rate of sedation and falls in patients with a history of SSRI and/or MAOI-induced sedation or falls, nor in patients treated with paroxetine alone (adjusted OR = 0.23, 95% CI = 0.12 to 1.05, p = 0.15). The combined risk of falls in paroxetine plus paroxetine-treated patients was 4.1% for SSRI vs. 7.3% for paroxetine alone (adjusted OR = 4.3, 95% CI = 1.5 to 10.7, p = 0.03).
Conclusions:Paroxetine is associated with a significant increase in sedation and falls in patients taking selective serotonin reuptake inhibitors (SSRIs) and paroxetine. The combination of paroxetine and paroxetine may be associated with a greater risk of drowsiness and/or falls, especially in those with a history of SSRI and/or MAOI-induced sedation or falls.
Disclosure:The authors have no relevant financial relationships that may limit this study.
PTSD, prothrombin time; SSRIs, selective serotonin reuptake inhibitors; MAOI, serotonin-norepinephrine reuptake inhibitor.
Chen,
Paroxetine is an SSRI antidepressant. It’s also used to treat depression, anxiety, and other disorders caused by certain mental health conditions. Paroxetine is the brand name for paroxetine hydrochloride, which is the generic name of the drug.
Paroxetine comes as an oral tablet, a delayed-release capsule, and as a liquid. It may be prescribed for different uses depending on the manufacturer and dosage form.
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) medication that works by increasing the levels of serotonin in the brain. This helps to alleviate the symptoms of depression and anxiety.
Paroxetine is also used to treat Parkinson’s disease and multiple sclerosis (MS).
It can be prescribed to relieve symptoms such as:
Paroxetine may also be used to treat other mental health conditions.
It works by helping to increase the amount of serotonin that is available in the brain. This helps to increase pleasure from the experience of pleasure in the body.
Paroxetine works by increasing the levels of serotonin in the brain. This helps to increase pleasure and help to improve mood.
Paroxetine is an SSRI medication and is commonly used to treat depression, anxiety, and other symptoms of depression, including:
Paroxetine may also be used to treat other conditions such as:
It is important to note that the exact mechanism of action of paroxetine is unknown.
Paroxetine works by increasing serotonin levels in the brain. This helps to improve mood and reduce symptoms of depression.
It is typically taken by mouth once a day. The maximum daily dose for depression and anxiety is usually 50 milligrams.
Paroxetine may be prescribed to relieve symptoms of depression, including:
If you are considering taking paroxetine, it is important to speak with your doctor before combining it with other medications or treatments.
You should never take Paroxetine if you have an allergy to paroxetine hydrochloride, or any ingredient in the medication.
Paxil can cause dizziness or drowsiness. Do not drive or operate machinery until you know how this medication affects you.
Paroxetine can interact with other medications, so it is important to inform your doctor about all the medications you are taking, including prescription and over-the-counter drugs, vitamins, and herbal supplements. If you have any questions or concerns, please do not hesitate to reach out to your doctor.
If you are using any other forms of antidepressants such as SSRIs or SNRIs, including over-the-counter medications, it is best to avoid them.
Paroxetine may increase the risk of seizures and bleeding in the digestive system, so it is important to take this medication regularly.
Paxil is a selective serotonin reuptake inhibitor (SSRI) used to treat major depressive disorder (MDD) by helping to restore an abnormal balance in the brain caused by the recurrence of depression in patients who have taken antidepressant medication for a long period of time. It is also used to reduce the risk of developing a wider range of side effects, including panic disorder, irritable bowel syndrome (GFRAND), and social anxiety disorder.
Paxil works by affecting serotonin in the nervous system. It also has some effects on the central nervous system, which in turn reduces the activity of other neurotransmitters in the brain.
Taking paxil can lead to several health conditions, including sleep apnoea, nerve pain, gastrointestinal symptoms, and changes in mood, which can be caused by a range of other conditions, including diet and lifestyle factors.
It is not recommended to take paxil if you are allergic to it, or to the components of its composition, such as fluoxetine (Prozac), paroxetine (Paxil), and another SSRI, noradrenaline, noradrenaline monophas Research has shown that fluoxetine is unlikely to be of use in patients allergic to fluoxetine or paroxetine (Paxil), as it is not an analogue of paroxetine or noradrenaline.
Paxil is not affected by food or drink. It works only with food and not with alcohol or other substances of abuse.
The most common side effects of paxil are nausea, diarrhea, tiredness, dizziness, and sweating. Consult your doctor if any of the symptoms worsen or persist for longer.
It is important to follow the instructions given by your healthcare provider to prevent the spread of the infection to others.
Common side effects of paxil:Some of the more serious side effects of paxil include:
If you experience any of the above-mentioned side effects, stop taking paxil and contact your doctor immediately:
If you have any questions about this medication, ask your doctor or pharmacist:
Paxil is not recommended for use in children and adolescents (aged below 18 years):
Paxil should not be taken by children and adolescents any age at the time of treatment.
Paxil can increase your risk of getting a rare blood clot (rare for men) and blood cells (fluid in the blood, white blood cells, plasma) infection.
Consumer Medicine Information (CMI)
Paxil (paroxetine hydrochloride) is a prescription medicine used to treat depression and other mental health conditions. This medicine is available only with your doctor's prescription.
Paxil (paroxetine hydrochloride) belongs to a group of medicines called selective serotonin reuptake inhibitors (SSRIs). It is used to treat depression and related mental health disorders. Paxil also helps treat anxiety and is used to treat other conditions as well.
Paxil (paroxetine hydrochloride) is used for the treatment of depression in adults. It works by increasing the levels of serotonin in the brain. Serotonin is a neurotransmitter that has a role in mood, sleep, and behavior. Paxil is also used to treat an enlarged prostate called benign prostatic hyperplasia. It is believed that Paxil helps reduce the symptoms of an enlarged prostate by stopping the flow of urine and/or by reducing the size of the gland.
Paxil was first approved by the FDA in 2002. It is not currently prescribed for the treatment of depression. Paxil also may be used for purposes not listed in this medication guide.
Paxil may interact with other medicines and foods. This medicine should not be taken with a specific drug.
The usual dose of Paxil (paroxetine hydrochloride) for adults is one tablet every 4 weeks. It can also be given as a combination with other antidepressants to treat depression. Your doctor may start you on a low dose of Paxil (paroxetine hydrochloride) and gradually increase your dose.
Swallow the tablet whole with a full glass of water. Do not crush or chew the tablet. Paxil (paroxetine hydrochloride) can be taken with or without food. Follow the directions on your prescription label.
Follow your doctor's instructions carefully. Take Paxil (paroxetine hydrochloride) with food or milk. Swallow the medicine with a full glass of water.
This medicine may be available under multiple brand names, depending on the manufacturer.
You must first notify your doctor or pharmacist of any other medications you are taking before using this medicine. Be sure to mention any of the following:.
This medicine may also be available under multiple brand names, depending on the brand:
Tricyclic antidepressants, such as imipramine and imipramine plus clomipramine, are sometimes used in combination with other antidepressants to treat anxiety and depression. Tricyclic antidepressants are medications that relax the muscles of the brain and increase the activity of serotonin in the brain.
Monoamine oxidase inhibitors (MAOIs), such as phenelzine and tranylcypromine, are sometimes used to treat depression. MAOIs treat depression by blocking the production of the neurotransmitter, norepinephrine, in the brain. Paxil (paroxetine hydrochloride) is an MAOI. Paxil (paroxetine hydrochloride) can also be used to treat anxiety disorder or depression. It is also sometimes used to treat depression in adults.
The generic name of Paxil (paroxetine hydrochloride), like all medicines, may vary based on the brand and manufacturer. This medicine may be available under multiple brand names, depending on the brand.
The dose of Paxil (paroxetine hydrochloride) for adults must always be the same.
Swallow the whole of this medicine with a full glass of water. Do not crush or chew the medicine. Paxil (paroxetine hydrochloride) can also be used with other antidepressants to treat anxiety disorder or depression.
Paxil (paroxetine hydrochloride) can be taken alone or with an antidepressant. You should not take Paxil (paroxetine hydrochloride) more than once a day.
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